Relative efficiency of unequal versus equal cluster sizes in cluster randomized trials using generalized estimating equation models
نویسندگان
چکیده
منابع مشابه
Unequal cluster sizes in stepped-wedge cluster randomised trials: a systematic review
OBJECTIVES To investigate the extent to which cluster sizes vary in stepped-wedge cluster randomised trials (SW-CRT) and whether any variability is accounted for during the sample size calculation and analysis of these trials. SETTING Any, not limited to healthcare settings. PARTICIPANTS Any taking part in an SW-CRT published up to March 2016. PRIMARY AND SECONDARY OUTCOME MEASURES The pr...
متن کاملPlanning a cluster randomized trial with unequal cluster sizes: practical issues involving continuous outcomes
BACKGROUND Cluster randomization design is increasingly used for the evaluation of health-care, screening or educational interventions. At the planning stage, sample size calculations usually consider an average cluster size without taking into account any potential imbalance in cluster size. However, there may exist high discrepancies in cluster sizes. METHODS We performed simulations to stu...
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Semi-parametric approaches based on generalized estimating equation (GEE) are widely used to analyze correlated outcomes in longitudinal settings. In this paper, we present a package CRTgeeDR developed for cluster randomized trials with missing data (CRTs). For use of inverse probability weighting to adjust for missing data in cluster randomized trials (CRTs), we show that other software lead t...
متن کاملCluster randomized controlled trials.
Cluster randomized controlled trial (RCT), in which groups or clusters of individuals rather than individuals themselves are randomized, are increasingly common. Indeed, for the evaluation of certain types of intervention (such as those used in health promotion and educational interventions) a cluster randomized trial is virtually the only valid approach. However, cluster trials are generally m...
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ژورنال
عنوان ژورنال: Biometrical Journal
سال: 2018
ISSN: 0323-3847
DOI: 10.1002/bimj.201600262